GPC1 promotes the growth and migration of colorectal cancer cells through regulating the TGF-β1/SMAD2 signaling pathway
Fig 1
Differential expression of GPC family genes in colorectal cancer (CRC) patients.
(A). Gene expression of six GPC family members in cancer tissues (473 samples) and non-tumor tissues (41 samples) in CRC patients (TCGA) using Student’s t test. Blue indicates non-tumor tissues, and red indicates CRC tissues. (B). Kaplan–Meier analysis revealed that CRC patients (453 samples, TCGA) with high GPC1 expression (225 samples, TCGA) and high GPC2 expression (225 samples, TCGA) had a poor prognosis compared with patients with low GPC1 and GPC2 expression.