The monoterpene 1,8-cineole prevents cerebral edema in a murine model of severe malaria
Fig 4
Treatment with 1,8-cineole induced ultrastructural changes in Plasmodium falciparum.
Control cells (A–D) showed the characteristic structure of trophozoites, including an extensive endoplasmic reticulum network (A, white rectangle; B) and digestive vacuoles filled with hemozoin crystals (A, C, and D arrows). In contrast, cells incubated with 972 μM 1,8-cineole showed loss of endomembrane integrity (E, white rectangle; F) and empty vacuoles resembling residual food vacuoles (E, G, and H, asterisks).