The gene knockout of angiotensin II type 1a receptor improves high-fat diet-induced obesity in rat via promoting adipose lipolysis
Fig 6
AT1aR knockout activated cAMP/PKA pathway.
A: Protein expressions of PKA, P-GSK-3β (ser9) and GSK-3β in adipose tissue. B: cAMP levels in adipose tissue. C: The proposed pathway for Ang II inhibiting adipose lipolysis. By binding to AT1R, Ang II activates inhibitory Gi which in turn reduces cAMP production. As a result, PKA activation is limited and HSL phosphorylation is decreased, leading to inhibitory of triglyceride hydrolysis. +p < 0.05 vs AT1aR-/—ND rats. Data were presented as Mean ± S.E.M. n = 6.