The voltage-gated Ca2+ channel subunit α2δ-4 regulates locomotor behavior and sensorimotor gating in mice
Fig 4
α2δ-4 KO mice exhibit diminished depression-like behavior in the tail suspension test.
For WT and α2δ-4 KO mice, the duration spent immobile in the tail suspension test (TST) (A-C) and forced swim test (FST, (D-F) was plotted against time (in 1-min bins) during the assay. A and D represent results for males and females combined while B,C,E,F show data disaggregated by sex. Smooth line represents exponential fits of the results. *p < 0.05; **p < 0.01; ***p < 0.001 by nonlinear regression.