The voltage-gated Ca2+ channel subunit α2δ-4 regulates locomotor behavior and sensorimotor gating in mice
Fig 1
α2δ-4 KO mice exhibit impaired PPI (A), Schematic of PPI session design.
Block 1 & 3 each consist of 6 test pulses (120 dB) alone trials. In block 2, animals were exposed to a period of no stimulation, the test pulse alone, or test pulses preceded by a PPI prepulse of 4, 8, or 12 dB. Each trial type (total of 12) was presented in a randomized order with varying intertrial interval. Each test pulse was 40 ms and prepulse was 20 ms in duration. (B) %PPI evoked by the indicated prepulse intensities. (C) Startle response amplitudes evoked by test pulses without prepulses. *p < 0.05; **p < 0.01; ***p < 0.001 by linear mixed model.