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The DNA co-vaccination using Sm antigen and IL-10 as prophylactic experimental therapy ameliorates nephritis in a model of lupus induced by pristane

Fig 3

Effects of prophylactic co-vaccination of Sm antigens with IL-10 or IFN-γ on anti-nRNP/Sm and anti-Su/Ago2 antibodies level.

Effects of prophylactic co-vaccination of Sm antigens with IL-10 or IFN-γ on anti-nRNP/Sm and anti-Su/Ago2 antibody production. Sera were tested for Panel A) anti-nRNP/Sm and Panel B) anti-Su/Ago2 antibodies by ELISA at six months after prophylactic co-vaccination and induction of lupus by pristane. Each symbol represents one mouse. Mann-Whitney test was used.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0259114.g003