Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19
Fig 3
Histogram plots of WHO ordinal scale scores before and after intervention in the early (A) and late CCP (B) compared to matched unexposed cohorts. Shown is a histogram of the change is WHO COVID-19 severity score from time of index to discharge in (A) early CCP recipients (gray solid bars) vs matched unexposed patients (black solid bars) (B) late CCP recipients (gray dashed bars) vs matched unexposed patients (black solid bars). WHO scores in (A) early CCP recipients were significantly improved at discharge (difference in mean -0.9, [95% CI -1.5 to -0.3]; p = 0.004) when compared to unexposed patients. Relative to the unexposed patients, early CCP recipients were nearly twice as likely to demonstrate an improvement in their WHO scores at discharge from baseline index day scores (OR 1.9,[95% CI 1.1 to 3.3]; p = 0.02). Among (B) late CCP recipients, there was no effect of CCP on WHO scores at discharge (difference in mean +0.6, [95% CI -0.4 to 1.5]; p = 0.23). The odds ratio for improvement at discharge was 0.6 (95% CI 0.3 to 1.3; p = 0.22).