Temporal determinants of tumour response to neoadjuvant rectal radiotherapy
Fig 3
Influence of delay to surgery on complete pathological response.
Delay to surgery (from completion of neoadjuvant therapy) plotted against rate of complete pathological response in 39 reviewed studies (27379 patients), coloured by included radiotherapy courses. Long course-only studies (>24 fractions) are coloured in red, short course-only studies coloured in blue, and studies including all fractionation schedules coloured in green. Data from the present study are indicated by red circles. Data points are fitted to a generalised additive model as implemented in R and this model is plotted as a trend line, with shaded areas indicating confidence intervals.