Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice
Fig 4
The activities of cytochrome P450 (CYP) 1A1, 1A, 3A11, 2B10, 2E1 and 2A5 in female offspring maternally exposed to a mixture of POPs at Control, Low or High doses (0x, 5000x or 100 000x human estimated daily intake, respectively). Samples were taken at 3 (n = 12), 6 (n = 14) and 9 (n = 14) weeks of age. Activities were measured as a rate of 7-ethoxyresorufin (CYP1A1), 7-methoxyresorufin (CYP1A), benzyloxyresorufin (CYP3A11), 7-pentoxyresorufin (CYP2B10) dealkylation, and p-nitrophenol (CYP2E1) and coumarin-7 (CYP2A5) hydroxylation. Boxplots consist of 25th, 50th (median) and 75th percentiles, whiskers (extending to 1.5 interquartile range) and outliers (•). Significant difference from Control (p ≤ 0.05) is marked by *.