Chronic stimulation of group II metabotropic glutamate receptors in the medulla oblongata attenuates hypertension development in spontaneously hypertensive rats
Fig 1
SBP at 1-week post-implantation surgery and Kaplan-Meier survival estimate in response to various LY379268 doses in SHRs.
The dose of 0.40 μg/day shows the best survival (P < 0.05) (B) and a lower SBP compared to doses of 1.3–40 μg/day (A). Death rate at 9-week post-operation was plotted against each dose on a logarithmic scale (C). The fitted curve as a standard sigmoidal function indicates that LD50 is approximately 4.63 μg/day. One rat that was alive at 9 weeks after administration met endpoints and was euthanized, so it was treated as 100% as a plot. *P < 0.05; statistical evaluations were performed using one-way ANOVA followed by Tukey’s test. Data in each group are the mean ± SEM from three or five rats. SBP, systolic blood pressure; SHR, spontaneously hypertensive rat.