Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
Fig 5
Resistance to single or double antibody combinations will develop quickly across a range of SARS-CoV-2 mutation rates.
A-D. The expected number of individuals infected with a specific single (A), double (B), triple (C), or quadruple (D) SARS-CoV-2 mutant viruses at different values of the per transmission mutation rate. E-H. Expected time to establishment of a successful single (E), double (F), triple (G), or quadruple (H) immune escape. The fitness benefit of resistance is 0.1. For all panels, the colors denote the total number of individuals with active SARS-CoV-2 infection. The fitness cost for each intermediate mutant is 0.05.