Identification and evolution of nuclear receptors in Platyhelminths
Fig 2
A novel zinc finger motif (CHC2) in the DBD of parasitic Platyhelminth HR96b.
Amino acid sequence alignment of the DBD of the Platyhelminth HR96b shows a novel NR zinc finger motif (CHC2) is present in parasitic Platyhelminth NRs. A histidine residue replaces the second cysteine residues in the D-Box of zinc finger II forming a novel CHC2 motif. Cs: Clonorchis sinensis, Dl: Dibothriocephalus latus, Ec: Echinococcus canadensis, Eca: Echinostoma caproni, Eg: Echinococcus granulosus, Em: Echinococcus multilocularis, Fh: Fasciola hepatica, Gs: Gyrodactylus salaris, Hd: Hymenolepis diminuta, Hn: Hymenolepis nana, Ht: Hydatigera taeniaeformis, Lg: Lottia gigantean, Mc: Mesocestoides corti, Ml: Macrostomum lignano, Of: Opisthorchis felineus, Ov: Opisthorchis viverrini, Px: Protopolystoma xenopodis, Sb: Schistosoma bovis, Sc: Schistosoma curassoni, Se: Spirometra erinaceieuropaei, Sh: Schistosoma haematobium, Sj: Schistosoma japonicum, Sm: Schistosoma mansoni, Sma: Schistosoma margrebowiei, Smt: Schistosoma mattheei, Sme: Schmidtea mediterranea, Sr: Schistosoma rodhaini, Ss: Schitocephalus solidus, Ta: Taenia asiatica, Tm: Taenia multiceps, Ts: Taenia saginata, Tr: Trichobilharzia regent, Tso: Taenia solium.