Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues
Fig 10
Intestine and kidney model structures for permeability rate-limited kinetics.
A: Intestinal structure, where Qintestine−blood flow to the small intestine, ST—saturable transport through paracellular space, AT–active transport, Diffc−diffusion into cells, DiffPC−paracellular diffusion, ATIN−active transport into cells by OCT3 and PAMAT transporters, ATOUT—active transport out of cells by OCT1 transporters; B: Renal structure, where Qkidney−renal blood flow, Qurine−urine flow, GFR—glomerular filtration rate, ATIN−active transport into cells by OCT2 transporters, ATOUT—active transport out of cells by MATE1, MATE2-K and OCT1 transporters.