Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues
Fig 2
Venous plasma (A), small intestine (B), liver (C), and stomach (D) following a single intravenous 50 mg/kg dose in mice. The red marks represent the experimental data’s concentration-time profiles with error bars representing standard deviation [1] and the blue lines represent the model simulations.