Pre-clinical left ventricular myocardial remodeling in patients with Friedreich’s ataxia: A cardiac MRI study
Fig 2
A-B: The LV mass-to-EDV (end-diastolic-volume) ratio in FRDA patients was significantly higher than in controls, indicative of a hypertrophic phenotype.
In FRDA, both the extracellular volume fraction and the intracellular lifetime of water were positively associated with the LV mass-to-EDV ratio, suggesting that a build-up of interstitial fibrosis and cardiomyocyte hypertrophy contribute to the observed hypertrophic phenotype. The color of data points identifies the Weidemann’s cardiomyopathy classification (gray = absent, orange = mild and blue = intermediate).