Human induced pluripotent stem cell-derived three-dimensional cardiomyocyte tissues ameliorate the rat ischemic myocardium by remodeling the extracellular matrix and cardiac protein phenotype
Fig 4
The three-dimensional human induced pluripotent stem cell-derived cardiac tissue (3D-hiPSC-CT) induced angiogenesis and angiogenic cytokine expression in the peri-infarct zone.
(A) Capillary density in the peri-infarct zone in the myocardial infarction rat heart 4 weeks after transplantation; scale bar = 100 μm. Sections were assessed by immunohistochemical staining for von Willebrand factor; * P < 0.01. (B) Immunostaining for isolectin B4 (white), TnT (green), human nuclei (red), and DAPI (blue); scale bar = 50 μm. (C) Quantitative polymerase chain reaction analysis of angiogenic cytokine-related gene expression (Vegf and Hgf: * P < 0.01.