Human induced pluripotent stem cell-derived three-dimensional cardiomyocyte tissues ameliorate the rat ischemic myocardium by remodeling the extracellular matrix and cardiac protein phenotype
Fig 2
Transplantation of three-dimensional human induced pluripotent stem cell-derived cardiac tissue (3D-hiPSC-CT) to the infarcted rat heart.
(A) Schematic illustration of construction of 3D-hiPSC-CT by the cell accumulation technique. (B) Hematoxylin and eosin (HE) staining image of 3D-hiPSC-CTs; scale bar = 100 μm. (C) Implantation of 3D-hiPSC-CT to the heart surface at the infarction site. (D) Left ventricular histology assessed 4 weeks after transplantation with HE staining. (E) Engraftment of 3D-hiPSC-CT to the heart surface at the infarction site; scale bar = 100 μm. Dashed yellow lines represent the areas of transplanted 3D-hiPSC-CT.