Human induced pluripotent stem cell-derived three-dimensional cardiomyocyte tissues ameliorate the rat ischemic myocardium by remodeling the extracellular matrix and cardiac protein phenotype
Fig 1
Fibronectin (FN)-gelatin (G)-coated human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) had improved tolerance to hypoxia.
(A) Schematic illustration of layer-by-layer filtration for nanofilm coating with FN and G on cell surfaces. (B) Lactate dehydrogenase production (LDH) assay. (C) Cell survival using Cell Counting Kit-8. (D) The beating area of cells assessed by Cell Motion Imaging System. * P < 0.01, ** P < 0.001.