Reduction of hyperoxic acute lung injury in mice by Formononetin
Fig 2
C57BL/6 mice were pretreated with Formononetin (FMN) or vehicle and exposed to hyperoxia or room air.
Numbers of neutrophil cells in bronchoalveolar lavage fluid (A), the wet to dry (W/D) weight ratio of lung tissues (B), pulmonary microvascular albumin permeability (C), interleukin (IL)-1β (D) and IL-6 (E) levels in lung tissues, pulmonary histopathological score (F), and lung tissue sections (G; original magnifications: ×100) were measured at 72 h after hyperoxia or room air exposure. Data are presented as mean ± SD. *P < 0.05 compared with vehicle-treated mice exposed to room air; #P < 0.05 compared with vehicle-treated mice exposed to hyperoxia.