NHD2-15, a novel antagonist of Growth Factor Receptor-Bound Protein-2 (GRB2), inhibits leukemic proliferation
Fig 7
Combinatorial addition of NHD2-15 and imatinib reduces proliferation of K562 cells.
1×105 K652 cells were incubated with 0, 15, 30, or 60 μM of NHD2-15 only (orange bars) and with 1 μM of imatinib (red and orange striped bars). After 72 hours, cells were enumerated by trypan blue exclusion. Dashed line denotes starting amount of cells. Bars represent the mean, and error bars represent SD; * p = 0.04, ** p = 0.03, *** p = 0.006; **** p = 0.001, ***** p < 0.001; n = 3 for K652 samples and n = 4 for combinatorial samples.