Bach1 promotes muscle regeneration through repressing Smad-mediated inhibition of myoblast differentiation
Fig 2
Muscle regeneration is impaired in Bach1-deficient mice.
(A) HE staining of tibialis anterior muscle sections from Bach1-deficient and WT mice 3, 7, or 21 days after muscle injury. Uninjured samples are also shown. Mononuclear cells infiltrated on day 3 (arrow heads). (B) Immunofluorescence staining with anti-Laminin antibody (green) of tibialis anterior muscle sections of Bach1-deficient and WT. Nuclei were stained with DAPI (blue). (C) CSA of injured muscle was calculated using myofibers with central nuclei. (n = 5–8; * p< 0.05).