Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells
Fig 5
Heatr9 gapmer transfection does not affect gene induction of interferons or all genes in proximity to Heatr9.
Heatr9 knockdown does not affect Ifnb1, Ifnl1, Ifnl2, or Ifna2 gene induction (A) or induction of interferon stimulated genes Isg15 or Oas1 (B). Genes near the Heatr9 loci and also found to be upregulated during influenza virus infection were also unaffected by Heatr9 knockdown, as determined by Mmp28 transcript induction (C). Each dot represents an independent experiment. Lines between data points indicate matched experiments. For statistical analysis, paired Student’s t tests were performed. No indication signifies a nonsignificant result.