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Medical honey for canine nasal intertrigo: A randomized, blinded, placebo-controlled, adaptive clinical trial to support antimicrobial stewardship in veterinary dermatology

Fig 2

Individual initial and final composite cytological scores of dogs treated with topical placebo or honey.

Legend: Panel A = placebo, panel B = honey. The composite cytological scores were calculated for each dog on Day-1 and 22 by adding the abundance scores (0 = none, to 4 = massive amounts) of cocci, rods, yeasts and inflammatory cells. Each line connects the Day-1 and Day-22 scores for one or more dogs sharing the same initial and final scores; boxplots at the margins of the graph illustrate the empiric distributions of the Day-1 and Day-22 scores. The tips of the bottom and top whiskers of the boxplots represent the 5th and 95th percentiles, the bottom and top of the gray-shaded box represent the 25th and 75th percentiles, and the horizontal line inside the box represents the median of the empirical distribution. The gray filled circles represent the individual values outside the 5th– 95th percentiles of the distribution.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0235689.g002