Marked variability in bioactivity between commercially available bovine colostrum for human use; implications for clinical trials
Fig 2
Effect of colostrum samples on NSAID-induced gastric injury.
Rats received 2ml oral gavage of control (BSA), or the most active or least active colostrum samples determined from Fig 1A (colostrum samples numbered 1 and 20), 30 minutes prior to receiving indomethacin (20mg/kg, sc), and 3h of restraint. Amount of macroscopic (A) and microscopic (B) damage was subsequently assessed. Microscopic scoring scheme described in [3]. Stomachs from animals that received NSAID + most active colostrum had essentially normal histology (C) whereas animals receiving NSAID + least active colostrum continued to show multiple erosions (D). Results expressed as mean +/- SEM of 8 animals per group. ** signifies p< 0.01 vs control and $ $ signifies p< 0.01 of best sample vs worst.