The transition from local to global patterns governs the differentiation of mouse blastocysts
Fig 8
Inhibition of FGF/MAPK signalling inhibits GATA6 clusters and promotes NANOG clusters (data V-VIII).
(A-B) Spearman’s correlation coefficients of GATA6 levels of a cell and the median GATA6 levels of its neighbours in PrE progenitor cells (A) or NANOG levels of a cell and the median levels of its neighbours in Epi progenitor cells (B) in control (light green or magenta, respectively; data V and VI) and PD03 treated embryos for 24 h or 20 h (dark green or magenta, respectively; data VII and VIII). The error bars represent the standard errors calculated by bootstrap sampling the experimental data 100 times The Mann-Whitney test with Bonferroni correction for the comparison with the null model results in statistically significant differences in all cases (**: p<0.01; not shown in the figure). Striped boxes indicate those populations composed of less than 108 cells. In those cases, no statistical analysis was performed. Details on the number of embryos and cells analysed are in S1 and S2 Tables 1. See also S11 and S12 Figs.