The retraction notice [1] for this article [2] included the following statements: ‘The western blot experiments shown in Fig 4 did not include general loading controls, and the authors did not report total Rb controls for the phospho-Rb (pRb) experiments’, ‘Furthermore, the lack of protein loading controls for the experiments in Figure 4 call into question the validity of the results.’
After publication of the notice, it was clarified that in Figure 4 of [2] “pRb” referred to total retinoblastoma protein rather than a phosphorylated form of this protein. As such, this point in the retraction notice is incorrect: “the authors did not report total Rb controls for the phospho-Rb (pRb) experiments.”
In addition, the authors noted that the total ERK and total Akt panels in Figure 4 provided information about protein loading across lanes. Additional loading controls were not requested during the re-evaluation of the article, the authors noted that such controls could in principle have been provided had they been requested.
References
- 1. The PLOS ONE Editors (2019) Retraction: EGFR Inhibition in Glioma Cells Modulates Rho Signaling to Inhibit Cell Motility and Invasion and Cooperates with Temozolomide to Reduce Cell Growth. PLoS ONE 14(9): e0222210. https://doi.org/10.1371/journal.pone.0222210 pmid:31479494
- 2. Ramis G, Thomàs-Moyà E, Fernández de Mattos S, Rodríguez J, Villalonga P (2012) EGFR Inhibition in Glioma Cells Modulates Rho Signaling to Inhibit Cell Motility and Invasion and Cooperates with Temozolomide to Reduce Cell Growth. PLoS ONE 7(6): e38770. https://doi.org/10.1371/journal.pone.0038770 pmid:22701710
Citation: The PLOS ONE Editors (2020) Correction to Retraction of: EGFR Inhibition in Glioma Cells Modulates Rho Signaling to Inhibit Cell Motility and Invasion and Cooperates with Temozolomide to Reduce Cell Growth. PLoS ONE 15(2): e0230016. https://doi.org/10.1371/journal.pone.0230016
Published: February 27, 2020
Copyright: © 2020 The PLOS ONE Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.