Neuroprotective effect of menaquinone-4 (MK-4) on transient global cerebral ischemia/reperfusion injury in rat
Fig 7
Diminished oxidative stress induced by I/R injury following MK-4 administration in I/R rat model.
(A) SOD activity in the hippocampus was reduced following I/R injury, however, this phenotype was backed to the control level after MK-4 injection in I/R rat model. (B) Nitrate/nitrite level increased significantly following I/R injury but MK-4 administration prevented it. Data are presented as mean±SEM. *** p < 0.001 compared to control and +++ p < 0.001 compared to I/R+MK4 group (n = 6).