Chemerin contributes to in vivo adipogenesis in a location-specific manner
Fig 3
Adipocyte development network in chemerin KO rats.
This network represents protein-protein interactions curated by the STRING database (edges with arrows) and gene expression data from this study (nodes). Edges are mapped according to the score given by the STRING app (v1.4.2) database correlating to the strength of data supporting their directional interaction. Scores for node mapping were determined by taking the 2-ΔCT from chemerin KO mesenteric adipocytes and dividing them by the 2-ΔCT from their WT counterparts. Comparisons of gene expression from KO and WT fats in Fig 2 that were not statistically significant were given a score of 1. Genes that were not incorporated into the STRING network (ccng2, ccna2, and tcf21) were not included in this figure. When expression is decreased with chemerin KO versus WT, the node will appear more red. When expression is unchanged, the node will appear yellow. These data were incorporated into the known physiology of the adipocyte and representative images of the WT and KO mesenteric adipose tissue to provide a hypothesis of the system discussed in this manuscript. Scale bars represent 100 um.