Codon and amino acid content are associated with mRNA stability in mammalian cells
Fig 7
Model of coordinated codon and amino acid-based effects on mRNA stability in mammalian cells.
Model of coordinate effects of codon and amino acid content on mRNA stability in mammalian cells. In this model, the stability of a given mRNA ORF sequence is related to functional cognate tRNA availability, which is in turn influenced by upstream amino acid concentrations. Stable mRNAs contain high proportions of codons with relatively high functional tRNA availability and are translated quickly. In contrast, mRNAs containing high proportions of codons with low tRNA availability are translated more slowly and targeted for decay via unknown protein effectors, which ultimately recruit decapping/deadenylation factors.