Potential effects of ursodeoxycholic acid on accelerating cutaneous wound healing
Fig 8
(a-c) H&E stained skin wounds sections of irradiated mice showing; (a) markedly destructed epidermal and dermal layers at zero-day post wounding. (b) disorganized and crinkle epidermal layer with numerous degenerated areas and scab and dermal inflammatory infiltrates and edema in non-treated wound at 5 days post wounding. (c) good, scarcely irregular re-epithelization and somewhat organized collagen fibers at 5 days post wounding in UDCA-treated wound. (d-f) Van Gieson’s stained sections showing; destructed and disorganized collagen fibers in non-treated wound (d and e) and its more deposition in UDCA-treated wounds (f). The quantitative analysis of area percent of type1 collagen fibers showing significant (P<0.05) more deposition of collagen fibers in UDCA- treated wounds. (g-l) Decreased expression of TGF-β1 and MMP-2 at day zero (g and j) and its increase at day 5 in non-treated wound (h and k) with more significant increase in both markers’ expression in UDCA-treated wounds (i and l). (m-o) Scares expression of NF-κB at zero day (m), and increased expression in both non-treated and UDCA-treated wounds 5 days post wounding.