Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures
Fig 6
Home-cage behavior in Scn1a+/- mice.
(A) 8-10week-old Scn1a+/- mice (n = 15, 8 male) were hypoactive compared with littermate WT mice (n = 13, 8 male, genotype x hour F21,546 = 2.21, p<0.01) without significant differences in sheltering or feeding entries (p>0.1). (B) Time budgets for A. (C) Scn1a+/- mice displayed lower overall total licking without a change in sucrose preference, together with increased total sleep time and mean sleep bout durations. (D) Light spot stimulation revealed no differences, but (E) with a day time “cage-swap”, Scn1a+/- mice displayed more rapid locomotor habituation and accelerated shelter entry. (F) Following PTZ (30m/kg), Scn1a+/- mice displayed greater immobility, quantified in (G). WT = wildtype. * p <0.05, ** p<0.01, *** p<0.001. Mean ± SEM is shown.