Developmental conservation of microRNA gene localization at the nuclear periphery
Fig 4
Perinuclear localization of microRNA gene loci in Bach1-/- thymocytes and BMDMs.
(A) miR-155 gene alleles distribution in wild type (wt) and Bach1-/- thymocytes and BMDMs. (B) Cumulative frequency graphs and KS-test for the comparison of miR-155 gene alleles distribution in wt versus Bach1-/- thymocytes and BMDMs before and after LPS stimulation for the indicated time points. (C) miR-146α gene alleles distribution in wt and Bach1-/- thymocytes and BMDMs. (D) Cumulative frequency graphs of miR-146α gene alleles NDs in wt and Bach1-/- thymocytes and BMDMs before and after LPS stimulation for the indicated time points. KS-test analysis results are portrayed on the table. (E) Allelic expression profile of pri-miRNA-155 and pri-miRNA-146α in naive (0h) and LPS stimulated (2h, 6h) BMDMs, following RNA-DNA FISH.