Adaptation of H3N2 canine influenza virus to feline cell culture
Fig 7
3D structure of H3-HA protein.
The 3D structure of HA of A/Aichi/2/1968 (H3N2) (PDB: 1HGG) is shown. (A) Amino acid positions, HA1-299 and HA2-107, at which mutations were observed in the CRFK-adapted CIVs, are colored orange or cyan, respectively. Amino acid positions, 107 and 116, in HA1, at which substitutions were observed in the feline isolates of CIV [28], are colored green. (B) Close-up view of the area surrounding HA1-299 is shown. A polar contact is formed between HA1-K299 and HA2-E69. (C) Close-up view of the area surrounding HA2-107 is shown. A polar contact is formed between HA2-T107 and HA2-K51.