Two novel and correlated CF-causing insertions in the (TG)mTn tract of the CFTR gene
Fig 3
The panel 1 shows an example of a WT forward sequence of the (TG)mTn tract; the panel 2 shows the case 1 forward sequence characterized by an anomalous number of 35 T in respect to the WT; the panel 3 shows the case 2 forward sequence characterized by an anomalous number of 76 T in respect to the WT and greater than the case 1. For each sample, the exact number of T were defined by different combination of forward and reverse sequencing as well as by fragment analysis (shown in Fig 2). See text for explanation.