BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis
Fig 2
Survival and weights of genetically modified mice.
A. Kaplan-Meier plot showing proportional survival of BrafCA (black line, n = 53) and BrafCATg(CD207-cre) (red line, n = 69) littermates. The median survival of BrafCATg(CD207-cre) mice was 19 days. P < 0.0001 by log-rank test. B. Weights of BrafCA (black dots) and BrafCATg(CD207-cre) (red dots) mice. Horizontal bars show means. p ≤ 8.9 x 10−7 by t-test for all time points. C. Kaplan-Meier plot showing proportional survival of BrafCAPtenloxP/loxP mice (black line, n = 41) and BrafCAPtenloxP/loxPTg(CD207-cre) littermates (red line, n = 38). The median survival of BrafCAPtenloxP/loxPTg(CD207-cre) mice was 20 days. P < 0.0001 by log-rank test. D. Weights of BrafCAPtenloxP/loxP (black dots) and BrafCAPtenloxP/loxPTg(CD207-cre) (red dots) mice. Horizontal bars show means. p ≤ 2.8 x 10−7 by t-test for all time points.