Glucocorticoids regulate pentraxin-3 expression in human airway smooth muscle cells
Fig 4
Transcriptional regulation of the PTX3 promoter by DEX.
HASMC were transiently transfected with the PTX3 promoter-luciferase construct and stimulated with different concentrations of DEX either alone (10−7 M, 10−6 M, and 10−5 M), or with TNF (10ng/ml) for 16 h. Values are presented as mean fold increase of luciferase activity normalized to the mock Renilla luciferase activity from 4 different donors. **P<0.01,***P<0.001 compared with TNF-stimulation group; ns, not significant compared with the medium group.