Deletion of ΔdblGata motif leads to increased predisposition and severity of IgE-mediated food-induced anaphylaxis response
Fig 4
Active IgE-MC-dependent anaphylaxis in WT and ΔdblGata mice.
(A) Oral antigen-triggered anaphylaxis experimental regime. (B) Diarrhea occurrence, (C) clinical score and (D) serum mast cell protease-1 (MCPT-1) levels in OVA-sensitized, i.g. Veh- or OVA-challenged BALB/c WT and ΔdblGata mice. The percentage in panel B represent the number of mice that experienced diarrhea over the number of total mice challenged as a percentage. Panels C and D were analyzed following eighth challenge of OVA-sensitized, i.g. Veh- or OVA-challenged mice. (C) and (D) line indicates mean and symbols represent individual mice. Values represent mean ± SEM; n = 6 to 10 mice per group. Statistical significance is *** p < 0.01. ND non detected.