Carnosine inhibits glioblastoma growth independent from PI3K/Akt/mTOR signaling
Fig 1
Influence of carnosine, rapamycin and Ly-294,002 on the expression of PDK4 and TBP in cells from the glioblastoma cell lines U87 and T98G.
Cells from the lines U87 and T98G were cultivated for 24 hours in the presence of carnosine (Car; 50 mM), rapamycin (Rapa; 25 nM), Ly-294,002 (Ly; 5 μM) or a combination of the compounds. Afterwards expression of PDK4 and TBP was measured and the fold change of expression under the influence of the compounds was determined. Asterisks above the columns indicate a significantly increased expression under the influence of the test compound compared to untreated control cells and the asterisks at the lines connecting columns indicate significant differences between the connected columns: ns: not significant; *: p<0.05; **: p<0.005; ***: p<0.0005.