Influenza M2 virus-like particle vaccination enhances protection in combination with avian influenza HA VLPs
Fig 8
Protection efficacy of mice from lethal influenza virus challenge.
Upon intramuscular immunization with VLPs and subsequent challenge infection with a lethal dose of A/Viet Nam/1203/2004 (rgH5N1) virus, mice body weight (A) and survival (B) were monitored daily for 10 days. Combinatorial VLPs showed significantly less body weight loss compared to combination M2e5x VLPs whereas all mice in Naïve + Challenge group reached endpoint. Data are expressed as mean ± SD, *P < 0.05.