Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys
Fig 4
Brains and spleens of C57BL/6 mice subjected to first challenge with monkey C- and L-BSE prions.
The brain (corresponding to dorsal lateral geniculate nucleus, hypothalamus, and ventral portion of the medulla oblongata) and spleen (corresponding to the white pulp) are shown. Ctrl (control inoculum); brain homogenates of a healthy monkey. dpi; days post-inoculation. HE; hematoxylin-eosin staining. PrP; immunohistochemical staining of PrPSc. GFAP; immunohistochemical staining of GFAP. The scale bar applies to all panels.