In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K
Fig 7
Mouse skin burn wound infection model.
Infected mice were treated with HPC vehicle (Vehicle), triple antibiotic ointment (TAO) or DGL13K in HPC vehicle (DGL13K), as described in Fig 6. The mice were imaged at 6 hours (left panel) and 24hours (right panel) after inoculation to determine RLU emitted by remaining live bacteria. The experiment was performed twice with 5 mice per group. Data are shown as mean±SEM after removal of statistical outliers (N = 7–10). Antibiotic treatment groups were compared to the vehicle control by one-way ANOVA with Dunnet’s multiple comparison post-test.