Whole blood transcriptomic profiles can differentiate vulnerability to chronic low back pain
Fig 1
Characterization of differential gene expression in whole blood from the chronic T5 versus normal (healthy pain-free) group and in the chronic T1 and acute group.
(A) Euclidean clustering demonstrates separation between the chronic T5 group compared with the normal control group. (B) Euclidean clustering demonstrates separation between the acute and chronic T1 group. (C) Volcano plot showing log fold change (LFC) for significantly differentially expressed genes (LFC ±0.58; FDR p-value ≤ 0.05; N = 3,479 shown in green circles) in the chronic T5 versus normal group. (D) Volcano plot showing log fold change (LFC) for significantly differentially expressed genes (LFC ±0.58; FDR p-value ≤ 0.05; N = 3,288 shown in green circles) in the chronic T1 compared with the acute group. (E) Pie charts depicting protein-coding and non-coding gene types for chronic T5 versus normal group (left) and chronic T1 versus acute group (right).