CD147 mediates intrahepatic leukocyte aggregation and determines the extent of liver injury
Fig 6
Anti-CD147 intervention reduces aggregation of macrophages, B cells, T cells and granulocytes during liver injury.
CCl4 treated C57Bl/6 mice liver tissue was stained for CD45 colocalisation with (A) F4/80, (B) B220, (C) Gr1 or (D) CD3, to identify immune subset specific aggregates. Representative images (left panel) and quantified immune cell-specific aggregates (right panel; calculated as at least one cell of interest per aggregate) in mice treated with CCl4 alone or CCl4 in conjunction with anti-CD147 intervention. Bar graphs represent mean ± SEM. Mann-Whitney test was performed to assess significance from control where * p<0.05, **p<0.01 (n = 5–7 per group). CCl4 = injury alone, αCD147 = anti-CD147 in CCl4 injury.