Cyclophosphamide and the taste system: Effects of dose fractionation and amifostine on taste cell renewal
Fig 6
AMF pretreatment protected SNAP-25+ cells in taste buds of circumvallate papillae from CYP.
Means + SEM of SNAP-25+ cells (top graph), total cells in taste buds (middle graph), and percent of SNAP-25+ cells/taste bud (bottom graph) over days post injection. Day 4 data are shown in the left half and day 10 data are shown in the right half of each graph. The bars (left to right) show means (+SEM) for saline, CYP, AMF and AMF+CYP drug groups for mice given their drug treatment either as a single dose or five doses. CYP injections reduced SNAP-25+ signal, total cell, and percent per taste bud measures at day 10 for mice receiving one inject of CYP. However, mice receiving 5 injections of CYP showed lower values for all three measures on 10 day and all but percentage measures on day 4. All measures of AMF+CYP mice indicated that AMF protected these mice from the effects of CYP. SNAP-25+ in mice receiving AMF appeared unaffected by either dosing method. a = P<0.05; b = P<0.01, c = P<0.005.