Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial
Fig 5
Correction of position-dependent bias resulting from use of the surface coil.
A custom phantom containing concentrations of magnevist with T1 values that span those anticipated in tumors were scanned using the surface coil. T1-weighted imaging of the phantom demonstrated a significant bias (A, left), which distorted the intensity of the magnevist tubes due to distance from the coil. Resulting measurements were unable to reflect the concentration-dependent signal appropriately (B). Application of an N4ITK bias correction, masked with a proton density weighted image (TR = 3000) reduced the effects of the coil bias (A, right), restoring linearity in the signal vs concentration curve (B).