Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies
Fig 2
Schematic view of the anti-IL17 antibody and chemical structure of the labeling reagent N-succinimidyl [1-14C]propionate ([14C]NSP).
The lysine side chains of the anti-IL17 antibody are shown as spheres colored in yellow, which could carry the 14C-propionate tag after the labeling reaction with [14C]NSP. The light and heavy chains of the anti-ILl7 are shown in light blue and violet, respectively. The cartoon representation of the Fab is based on coordinates of an in-house X-ray structure. For the Fc the coordinates of the pdb entry 1HZH were used. The hinge region is shown as dashed lines. The image has been generated using the program Pymol (The PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC).