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Strawberry seed extract and its major component, tiliroside, promote ceramide synthesis in the stratum corneum of human epidermal equivalents

Fig 5

Effect of SSE and tiliroside on the mRNA expression levels of GCS and GBA.

3DHEEs models were treated with SSE (1 and 3 μg/mL) or tiliroside (0.1 and 0.3 μg/mL) for 4 days, and total RNA was extracted. mRNA expression levels of GCS (A, B) and GBA (C, D) were determined by real-time qRT-PCR. mRNA expression of GAPDH was used for correction of each mRNA expression. Each column represents mean and S.E. (n = 3–4). Asterisks denote significant difference from control at *P < 0.05 and **P < 0.01.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0205061.g005