LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response
Fig 4
Na-lactate and Lactic Acid effects on HIF-1 and VEGF-A, in LDH-A KD and control NC cells.
Assessment of HIF-1 activation using the HRE reporter system (A) and its downstream target—VEGF165 (B). Measurements followed a 24 h incubation in 30 mM Lactic Acid or 30 mM Na-Lactate. Statistics: *p<0.05; **p<0.01; ***p<0.005; ****p<0.001.