Urinary steroid profiling in women hints at a diagnostic signature of the polycystic ovary syndrome: A pilot study considering neglected steroid metabolites
Table 1
Steroid hormone excretion in women with the polycystic ovary syndrome (PCOS) compared to healthy control women.
The available number of participants (N) and the distribution described by median and 25th-75th quantile for the PCOS and control group are indicated for each steroid. Between-group differences are determined by Mann–Whitney U test (MWU) and the corresponding P values are indicated. Univariable and multivariable models were calculated by linear regression. Univariable models contain the PCOS-/control-group as predictor variable (with controls as reference group). Multivariable models contain in addition the covariables age and BMI. The dependent variables in the models were transformed as indicated. The β coefficients and the corresponding 95% confidence intervals (CI) are reported in the transformed scale and the corresponding P values are indicated. Note, only steroid hormones with a significant difference in the amount excreted in 24 hours in women with PCOS compared to healthy controls are shown here. Results for all 40 steroid hormones measured are displayed in S2 Table.