Cannabinoid 1 receptor signaling on GABAergic neurons influences astrocytes in the ageing brain
Fig 4
Representative photomicrographs of GFAP-immunopositive astrocytes in the hippocampal CA1 (A) and CA3 (B) layers from 2- and 24-months-old GABA-Cnr1+/+ and GABA-Cnr1−/− mice. The width of the panels is 100 μm. (sp) stratum pyramidale, (sl) stratum lucidum, (sr) stratum radiate, (slm) stratum lacunosum-moleculare. Spatial distribution of GFAP-immunopositive areas within layers of the hippocampal CA1 (C) and CA3 (D) regions in 2-, 6-, 12- and 24-month-old GABA-Cnr1-/- and GABA-Cnr1+/+ littermates, respectively * p < 0.05: ** p < 0.01; *** p < 0.001 significantly different compared to 2-months-old mice from the same genotype. Color of the asterisk refers to the layer indicated in the figure legend. n = 5–6 per age group and genotype. Symbols indicate mean values and error bars standard error of means.